NOTE: By submitting this form and registering with us, you are providing us with permission to store your personal data and the record of your registration. In addition, registration with the Medical Independent includes granting consent for the delivery of that additional professional content and targeted ads, and the cookies required to deliver same. View our Privacy Policy and Cookie Notice for further details.

You can opt out at anytime by visiting our cookie policy page. In line with the provisions of the GDPR, the provision of your personal data is a requirement necessary to enter into a contract. We must advise you at the point of collecting your personal data that it is a required field, and the consequences of not providing the personal data is that we cannot provide this service to you.


Don't have an account? Subscribe

Disease remission associated with 80% reduction in cardiovascular outcomes

By Mindo - 17th Jul 2019

Medical stethoscope and heart on wooden table on green backgroundMedical stethoscope and clipboard on wooden table on green background

Remission in patients with rheumatoid arthritis (RA) is associated with an 80 per cent reduction in risk of cardiovascular outcomes, the results of a study presented at EULAR 2019 show.

“The heightened risk of cardiovascular disease in patients with rheumatoid arthritis is in large part a consequence of uncontrolled inflammation. By demonstrating that remission of rheumatoid arthritis is associated with a reduction in cardiovascular complications, these results really emphasise the importance of more effective control of disease, beyond symptom management alone,” said Prof John D Isaacs, Chairperson of the Abstract Selection Committee, EULAR.

The study analysed data from 797 patients with RA over three years and found that patients in remission had an 80 per cent reduced risk of clinical cardiovascular disease, defined as heart attack, congestive heart failure, or stroke (odds ratio (OR): 0.20, 95% CI: 0.09-0.95, p=0.041). The authors also demonstrated a 75 per cent reduced risk of pre-clinical cardiovascular disease in patients in remission, defined as lesions on arteries detected by ultrasound (OR: 0.25, 95% CI: 0.11-0.56, p=0.001).

The study also looked at traditional cardiovascular risk factors and the analysis identified type 2 diabetes as being significantly associated with both cardiovascular outcomes, clinical (OR: 6.21, 95% CI: 2.19-17.71, p=0.001) and pre-clinical cardiovascular disease (OR: 4.50, 95% CI: 1.74-11.62, p=0.002). In addition, pre-clinical cardiovascular disease was significantly associated with high blood pressure (OR: 2.03, 95% CI: 1.04-4.14, p=0.042), ACPA (OR: 2.36, 95% CI: 1.19-4.69, p=0.002) and mean values of CRP during follow-up (OR: 1.07, 95% CI: 1.03-1.14, p=0.040).

Leave a Reply

Latest
Latest Issue
The Medical Independent 20th February
The Medical Independent 20th February 2024

You need to be logged in to access this content. Please login or sign up using the links below.

Most Read