NOTE: By submitting this form and registering with us, you are providing us with permission to store your personal data and the record of your registration. In addition, registration with the Medical Independent includes granting consent for the delivery of that additional professional content and targeted ads, and the cookies required to deliver same. View our Privacy Policy and Cookie Notice for further details.

You can opt out at anytime by visiting our cookie policy page. In line with the provisions of the GDPR, the provision of your personal data is a requirement necessary to enter into a contract. We must advise you at the point of collecting your personal data that it is a required field, and the consequences of not providing the personal data is that we cannot provide this service to you.

Don't have an account? Subscribe

High-density lipoprotein particles undergo metabolic activation during obesity

By Mindo - 24th Oct 2019

According to research presented in an oral presentation at the IES Annual Meeting, high-density lipoprotein (HDL) particles undergo metabolic activation during obesity and become dysfunctional.

Researchers concluded that “determination of MHI (metabolic HDL index) may provide a novel indicator of metabolic health and guide clinical decision-making”.

The study was based upon a hypothesis following a study carried out on mice, which demonstrated the enrichment of pro-inflammatory proteins on HDL from obese mice, who were fed a saturated-fat diet compared with a monosaturated-fat diet. This study hypothesised that HDL function and proteomic composition would be modulated in obese humans, similarly to those of the mice.

The study was carried out with a cohort of 108 obese subjects and 129 normal-weight (NW) subjects. The obese subjects were categorised into ‘metabolically healthy obese’ (45 subjects) and ‘metabolically unhealthy obese’ (65).

Efflux function of small and large HDL particles and paraoxonase-1 activity was determined. Researchers then performed HDL-proteomic analysis on subgroups of age- and sex-matched subjects. The groups were made of eight-to-12 people.

The study found that ABCA1-independent (p<0.001) efflux to HDL and paraoxonase-1 activity (p<0.001) were reduced significantly, while ABCA1-dependent efflux was preserved in obese subjects compared with NW controls.

The metabolically unhealthy obese cohort showed an intermediate HDL-proteome footprint. An MHI score generated based upon the proteomic data could “significantly delineate” between the metabolically healthy and the metabolically unhealthy obese groups; this was “one of the strongest correlates with multiple components of the metabolic syndrome”.

This research was carried out by the UCD Diabetes Complications Research Centre, UCD Conway Institute, University College Dublin, the Department of Endocrinology at St Vincent’s University Hospital, Dublin, and Tallaght
Hospital, Dublin.

Leave a Reply

Latest Issue
The Medical Independent 20th February 2024

You need to be logged in to access this content. Please login or sign up using the links below.

Most Read