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ESC Congress 2021 round-up

By Mindo - 17th Sep 2021 | 88 views

Microphone in front businesspeople blurred in conference meeting room

Priscilla Lynch presents a round-up of some of the most topical research presented at the European Society
of Cardiology (ESC) 2021 Congress, which took place virtually from 27-30 August.

Flu jab after heart attack should become standard care

Influenza vaccination reduces the risk of all-cause death, myocardial infarction, or stent thrombosis at 12 months in hospitalised patients with myocardial infarction or high-risk coronary disease, according to late breaking research presented in a Hot Line session at the ESC 2021 Congress. During influenza epidemics more people die from cardiovascular causes than during non-epidemic periods, the researchers noted. Observational studies have suggested a protective effect from influenza vaccination on cardiovascular events, and single-centre randomised trials have supported these findings. Influenza vaccination is recommended for patients with heart disease, but is not part of standard hospital care following an acute myocardial infarction.The IAMI trial was the largest randomised trial to date to evaluate whether influenza vaccination improves outcomes following myocardial infarction or percutaneous coronary intervention in high-risk patients with coronary artery disease.

The trial was conducted at 30 hospitals in eight countries (Sweden, Denmark, Norway, Latvia, the UK, Czech Republic, Bangladesh, and Australia) over four influenza seasons spanning October 2016 through February 2020. Participants were randomly assigned in a 1:1 ratio to receive either the influenza vaccine or placebo within 72 hours of an invasive coronary procedure or hospitalisation. The primary endpoint was a composite of all-cause death, myocardial infarction, or stent thrombosis at 12 months. A hierarchical testing strategy was used for the key secondary outcomes of all-cause death, cardiovascular death, myocardial infarction, and stent thrombosis.

The trial was halted prematurely on 7 April 2020 by the data safety and monitoring board due to the Covid-19 pandemic after the enrolment of 2,571 patients (58 per cent of the target). The average age of participants was 60 years and 18 per cent were women.The primary composite endpoint occurred in 67 patients (5.3 per cent) in the vaccine group and 91 (7.2 per cent) in the placebo group (HR 0.72; 95% CI 0.52–0.99; p=0.040). Regarding secondary endpoints, death from any cause occurred in 37 patients (2.9 per cent) in the vaccine group and 61 (4.9 per cent) in the placebo group (HR 0.59; 95% CI 0.39–0.89, p=0.010). Rates of cardiovascular death were 2.7 per cent and 4.5 per cent, respectively (HR 0.59; 95% CI 0.39–0.90, p=0.014). There was no difference between groups in the rate of myocardial infarction, which occurred in 25 (2.0 per cent) and 29 (2.4 per cent) patients in the vaccine and placebo groups, respectively (HR 0.86; 95% CI 0.50–1.46; p=0.57). Serious adverse events were rare and of similar type and incidence in both groups. injection site reactions like pain, redness, swelling, and hardening were reported significantly more often in patients assigned to influenza vaccine. Principal investigator Prof Ole Fröbert of Örebro University, Sweden said: “The IAMI trial found that in patients with myocardial infarction or high-risk coronary disease, early influenza vaccination resulted in a lower risk of the composite of all-cause death, myocardial infarction or stent thrombosis at 12 months compared with placebo. Our findings suggest that influenza vaccination should be considered as part of in-hospital treatment after myocardial infarction.

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