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Gout in the 21st century

An overview of the latest diagnostic and treatment approaches for this increasingly common disease Gouty arthritis was one of the earliest diseases to be recognised as a clinical entity. It was first identified by the Egyptians in 2640 BC and was later further described by Hippocrates in the fifth century BC who referred to it…

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Osteoporosis: Risk factors, diagnosis, and treatment

Osteoporosis meaning ‘porous bone’ is a progressive disease that occurs when the body loses bone mass and increases bone fragility and susceptibility to fractures. Osteoporosis affects up to 50 per cent of women and 25 per cent of males over the age of 50 years. An estimated 300,000 people in Ireland have osteoporosis. In the…

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Microscopic haematuria: Update to the AUA guidelines

Haematuria is one of the most common reasons for referral to a urologist and is a frequent reason for patients to consult GPs. Most urologists worldwide follow guidance set out by two international societies: The American Urological Association (AUA) and the European Association of Urology (EAU). Both provide robust and detailed guidelines on the management…

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Lung cancer and late detection a tale of stigma, shame, and hope

As the single biggest cause of cancer death in Ireland and worldwide, lung cancer remains a major health and socioeconomic burden Lung cancer is Ireland’s biggest cancer killer. It is the third most commonly diagnosed invasive cancer in males and the second most commonly diagnosed invasive cancer in females, claiming over 1,800 lives annually. While…

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Updated NCCP GP breast cancer referral guideline

Ten years after its creation, the National Breast Cancer GP Referral Guideline has been updated and the new version will be rolled out imminently Breast cancer is the most common invasive cancer affecting women in Ireland, with 3,667 cases annually. The median age at diagnosis is 55-59 years. Survival is increasing, with a five-year survival…

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Insights into wound repair

Attendees at UCD’s Charles Institute Seminar Series recently heard a presentation from Assist Prof Oliver Harrison of the Benaroya Research Institute, who spoke about the characteristics of tissue repair at the cellular level The Charles Institute, Ireland’s national dermatology research and education centre, hosts a range of guest speakers who cover a variety of topics…

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Covid-19 associated coagulopathy and thrombosis

S KELLIHER, E O’ROURKE, SHANE P COMER, PAULINA B SZKLANNA, LUISA WEISS, PB MAGUIRE, F NÍ ÁINLE, and B KEVANE Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the causative pathogen associated with the novel human viral illness, Coronavirus disease 2019 (Covid-19). This disease was first described in Wuhan, China in December 2019 and to…

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ASH guidance on Covid-19 and CLL

BY AMERICAN SOCIETY OF HEMATOLOGY (ASH) with input from DRS MAZYAR SHADMAN, JOHN BYRD, MICHAEL HALLEK, JENNIFER BROWN, PETER HILLMEN, ANTHONY MATO and PAOLO GHIA ASH experts answer frequently asked questions about Covid-19 and chronic lymphocytic leukaemia (CLL) (Version 4.0; last updated November 17, 2020) Are all or a specific group of patients with CLL…

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ASH 2020: Genome editing and cellular therapies show promise for treating blood disorders, cancers

Three studies presented during the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition report promising results in the use of cutting-edge genome editing and cellular therapies for hard-to-treat blood disorders and cancers. In the first study, researchers used CRISPR/Cas9 to treat two inherited blood disorders, beta thalassaemia and sickle cell disease (SCD). The…

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ASH 2020: Covid-19 risk in those with blood cancers

Three studies presented during the 62nd ASH Annual Meeting and Exposition offer glimpses into the complexities of Covid-19 infection, who is at greatest risk of severe illness and complications, and a potential off-the-shelf T-cell-based treatment. The first of the three studies sheds light on which individuals with blood cancers are most vulnerable to severe illness…

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