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Updated EULAR recommendations on gout

Priscilla Lynch outlines the new 2018 updated European League Against Rheumatism (EULAR) evidence-based recommendations for the diagnosis of gout In 2006, EULAR produced its first evidence-based recommendations for the diagnosis of gout. Since then, major advances have been made with regard to imaging, clinical diagnosis and understanding of the natural history of the disease. A…

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Down syndrome and inflammatory arthritis

There are distinct immune cell responses in children with Down syndrome and inflammatory arthritis, which are associated with an aggressive erosive disease Down syndrome (DS) is a common chromosomal disorder characterised by the presence of a full or part of a third copy of chromosome 21. A variety of medical conditions are associated with DS, including…

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Can we predict disease onset for rheumatoid arthritis?

There is a major need to be able to predict the efficacy of drugs for the treatment of rheumatoid arthritis Rheumatic and musculoskeletal diseases (RMD) affect up to 60 per cent of the 120 million EU citizens, at an estimated cost of €240 billion, with direct costs of 2 per cent EU GDP. Rheumatoid arthritis…

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PARP inhibitors in cancer – shifting the paradigm to frontline treatment

The last decade has seen major advances in oncology therapy with the addition of PARP inhibitors, with significant updated data on their usage across a range of cancers in the last 12 months Tubo-ovarian cancer The last 12 months has continued to see PARP inhibitors lead the field as regards therapeutic advancement in advanced tubo-ovarian…

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The 2019 European Society for Medical Oncology (ESMO) Asia Congress, Singapore

First China-manufactured trastuzumab biosimilar HLX02 global phase 3 trial met primary endpoint in breast cancer outcomes The trastuzumab biosimilar HLX02 achieved similar overall response rate to reference trastuzumab in women with human epidermal growth factor receptor 2-positive (HER2+) recurrent or previously untreated metastatic breast cancer, according to a large, randomised phase 3 study reported at…

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Breast cancer in Ireland

Priscilla Lynch reports on the latest data on breast cancer incidence, treatment, and outcomes in Ireland The National Cancer Registry of Ireland (NCRI) recently released a new trends report for breast cancer (Cancer Trends: Breast cancer 1994-2016). This report shows that the rate of new cases of invasive breast cancer in Irish women has stabilised…

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2019 Annual Meeting of the Radiological Society of North America (RSNA)

Minimally-invasive procedure relieves tremors in Parkinson’s patients A procedure that applies pulses of focused ultrasound to the brain is safe and effective for reducing tremors and improving quality of life in people with essential tremor (ET) or Parkinson’s disease (PD) tremor, according to a new study presented at the 2019 Annual Meeting of the Radiological…

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Lack of awareness about autoimmune hepatitis

Autoimmune hepatitis (AIH) is on the rise but remains under-diagnosed and under-recognised, the 2019 ISG Winter Meeting heard Irish-born AIH expert Prof Dermot Gleeson, Professor of Hepatology at Sheffield Teaching Hospitals, UK, gave a tour de force update on AIH, a corticosteroid-responsive liver disease arising consequent to immunogenetic and environmental risk factors, which can be…

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POCUS: Breaking the sound barrier

The Mater Misericordiae University Hospital, Dublin, has opened a centre for point-of-care ultrasound education Have you ever stood at the bed of a critically-shocked patient, wondering if they have cardiac tamponade and was not sure if the heart sounds were ‘muffled’? Been uncertain if your dyspnoeic patient has heart failure or infection? Not 100 per…

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Hospital-acquired venous thromboembolism

There is an urgent need for implementation of VTE prevention policies in Irish hospitals Venous thromboembolism (VTE) continues to represent a major cause of cardiovascular death in developed countries, accounting for more deaths annually than road traffic accidents, retroviral disease, breast cancer and prostate cancer combined. While the pathophysiology of VTE is clearly complex and…

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