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Gastro-oesophageal reflux disease (GORD)

An overview of the risk factors, symptoms, and latest treatment approaches to GORD Gastro-oesophageal reflux disease (GORD) is a common disorder of the GI system. A higher incidence occurs in people living in western countries, affecting up to 20 per cent of the population. GORD is defined as “symptoms or complications resulting from the reflux…

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Irritable bowel syndrome (IBS) in focus

A clinical overview of the characteristics of IBS and the various treatment options Irritable bowel syndrome (IBS) the most commonly-diagnosed gastrointestinal condition, can affect up to one-in-five people at some point in their lives. This could be an underestimation of the condition, as it is thought that many suffering with IBS do not seek medical…

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Treating and managing Crohn’s disease and UC

Siún Tobin, MPSI Senior Pharmacist, Our Lady’s Hospice and Care Services. Specialising in cancer care, palliative care, and medicines information A clinical overview of Crohn’s disease and ulcerative colitis presentation and management strategies Crohn’s disease (CD) and ulcerative colitis (UC) are collectively known as inflammatory bowel disease (IBD). An estimated 40,000 people in Ireland live…

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EULAR recommendations for the management of Sjögren’s syndrome with topical and systemic therapies

The European League Against Rheumatism (EULAR) has recently published recommendations for the management of patients with Sjögren’s syndrome with topical and systemic therapies.          The therapeutic management of Sjögren’s syndrome has not changed substantially in recent decades: Treatment decisions remain challenging in clinical practice, without a specific therapeutic target beyond the relief of symptoms as the…

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Psoriatic arthritis — epidemiology, diagnosis and treatment

Psoriatic arthritis (PsA) is a chronic, systemic inflammatory disease of the joints and skin characterised by the presence of dactylitis, enthesitis, nail psoriasis and spondylitis. Clinical manifestations also include skin psoriasis, distal interphalangeal (DIP) arthritis, osteoperiostitis, oligoarthritis and arthritis mutilans. It is one of a group of disorders known as the spondyloarthropathies. PsA is variable…

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Round-up of the most topical research presented at EULAR 2020

Study on Covid-19 in rheumatic/musculoskeletal diseases provides reassurance on medications A current study published in the run-up to the European Congress of Rheumatology of the EULAR analysed, for the first time, 600 Covid-19 cases in rheumatic disease patients from 40 countries and investigated the impact of the choice of rheumatic disease therapy on potential hospitalisation…

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Side-effect management of anti-cancer immunotherapy agents

Immunotherapy is an anti-cancer therapy that attempts to reactivate the patient’s own immune system to recognise and target cancer cells. Immunological agents frequently seen in practice are pembrolizumab, nivolumab, ipilimumab, durvalumab, and atezolizumab but there are many more in development. The growing use of immunotherapy has led to an increased frequency of novel toxicities known…

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An update on Li-Fraumeni syndrome

Li-Fraumeni syndrome (LFS) is an autosomal dominant cancer predisposition syndrome caused by germline variants in the TP53 gene. It is characterised by a high risk of developing a broad range of malignancies with an associated lifetime risk of cancer of ≥70 per cent for men and ≥90 per cent for women. The commonest cancers in…

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A round-up of the ASCO Annual Meeting 2020

Early data shows cancer progression associated with increased risk of death in patients with Covid-19 In patients with cancer and Covid-19, cancer that is progressing was independently associated with an increased risk of death, according to data from the Covid-19 and Cancer Consortium (CCC19) registry presented as part of the virtual scientific programme of the…

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Standard operating procedure for venesection during Covid-19

The latest guidance from the HSE on performing venesections in light of the current pandemic To develop a standard operating procedure (SOP) for registered nurses/doctors to perform venesection procedure while restarting venesection services locally, or where agreed by clinicians and hospital managers for patients being treated in the blood transfusion service or in private hospital…

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