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Systemic lupus erythematosus –diagnosis and management

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterised by the presence of autoantibodies, which can cause inflammation in various organs. It is more common in women and amongst non-Caucasian populations. Although children can be affected with SLE, it is less prevalent in this population and without the gender bias seen in adults. The…

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Osteoarthritis in focus

Evidence-based management of osteoarthritis needs to address the underutilisation of corerecommended treatments and over-reliance on surgery and pharmacological agents Osteoarthritis is a chronic degenerative joint disorder characterised by cartilage loss. It is a leading cause of pain and disability, affecting 3.3-to-3.6 per cent of the global population and is the most common form of arthritis…

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Opening the door to new treatment options for vitiligo patients

Attendees at UCD’s Charles Institute Seminar Series heard a presentation by Dr Mitesh Kumar Dwivedi of theUka Tarsadia University in Gujarat, India, who discussed the complex role of regulatory T-cells in vitiligo andhow they can present opportunities for therapeutic strategies The Charles Institute, Ireland’s national dermatology research and education centre, hosts a range of guest…

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Irish-developed test more accurately predicts risk of distant metastasis in early-stage breast cancer patients

Breast cancer is the most common type of cancer globally, with over 2.3 million occurrences every year. Up to one-in-eight women in Ireland will develop breast cancer in their lifetime, with over 3,700 diagnoses per year. Recurrence after surgical resection is an ongoing challenge in the management of early-stage breast cancer, particularly in cases where…

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Is antibiotic use linked to increased colorectal cancer risk?

Antibiotic usage may be contributing to the increase in early-onset colorectal cancer (CRC) cases observed in recent years, suggests a study presented at the European Society for Medical Oncology (ESMO) World Congress on Gastrointestinal Cancer 2021. Study author Sarah Perrott, a medical student at the University of Aberdeen in Scotland, noted that rates of early-onset…

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CRC screening confers long-term benefits

Colorectal cancer (CRC) screening has been introduced in many countries with the most frequently used methods being repeated endoscopy (usually colonoscopy, but also less invasive sigmoidoscopy) and faecal testing. However, the latest findings of the randomised controlled Italian Flexible Sigmoidoscopy Screening Trial (SCORE), as outlined in a recent article in the Annals of Internal Medicine,…

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Updates in the management of ovarian cancer

Ovarian cancer is a leading cause of morbidity and mortality among women all over the world. Many patients remain asymptomatic until they develop more advanced disease. Subsequent symptoms can often vary in severity and character making it difficult to diagnose. In Ireland, on average 400 cases of ovarian cancer are diagnosed every year.The five-year net…

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Embracing technological innovation can make Ireland a world leader in radiology

As early and pragmatic adopters of new technologies, Irish hospitals can become centres of excellence when it comes to radiology Healthcare is being revolutionised with all areas benefiting. In the area of radiology, we are seeing many benefits, and if the sector can manage to embrace the opportunities which are now within our grasp, patients,…

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Long Covid: Navigating uncharted waters

The constellation of prolonged Covid-19 symptoms is referred to as ‘long Covid’ or post-acute sequelae of SARS-CoV-2 infection (PASC) With the Covid-19 pandemic evolving into an endemic strain, there is a growing urgency to look beyond Covid-19 mortality figures to morbidity related to the increasing number of patients with ongoing symptomatic sequelae from acute SARS-CoV-2…

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Lifting the lid on extracellular vesicles

Attendees at UCD’s Charles Institute Seminar Series heard a presentation by Dr Graça Raposo of the Institute Curiein France on the role of extracellular vesicles in regulating skin in health and disease The Charles Institute, Ireland’s national dermatology research and education centre, hosts a range of guest speakers who cover a variety of topics ranging…

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